Abstract
Seventeen patients undergoing tonsillectomy received cefpodoxime proxetil orally in a dose equivalent to 100 mg cefpodoxime 4, 7 or 12 h before operation. Plasma and tonsillar tissue concentrations of cefpodoxime were assayed by a microbiological method. Tonsillar tissue concentrations after 4 and 7 h were 0 multiplied by 24 and 0 multiplied by 09 mg/kg respectively--being 23% of the plasma concentration. The tonsillar tissue concentration after 12 h was less than 0 multiplied by 06 mg/kg. As the MIC for Streptococcus pyogenes is less than 0 multiplied by 06 mg/l, cefpodoxime proxetil may be of value in acute tonsillitis.