Abstract
Eighteen patients of either sex with pleural effusions underwent aspiration 3, 6 or 12 h after receiving a single oral dose of cefpodoxime proxetil equivalent to 200 mg cefpodoxime. The mean concentrations of cefpodoxime in pleural fluid were, respectively, 0 multiplied by 62, 1 multiplied by 84 and 0 multiplied by 78 mg/l for these three time intervals, the corresponding ratios between pleural fluid and plasma concentrations being 0 multiplied by 24, 0 multiplied by 67 and 1.07. There is good penetration of cefpodoxime into pleural fluid. Concentrations between 3 and 12 h after dosing were equal to or above the MIC sub(90) for most of the organisms commonly found in lower respiratory tract infections.