Abstract
HIV/AIDS big data analytics evolved as a potential initiative enabling the connection between three major scientific disciplines: (1) the HIV biology emergence and evolution; (2) the clinical and medical complex problems and practices associated with the infections and diseases; and (3) the computational methods for the mining of HIV/AIDS biological, medical, and clinical big data. This chapter provides a review on the computational and data mining perspectives on HIV/AIDS in big data era. The chapter focuses on the research opportunities in this domain, identifies the challenges facing the development of big data analytics in HIV/AIDS domain, and then highlights the future research directions of big data in the healthcare sector.