Abstract
Looking back upon the past decade, functionalized noble metal nanoparticles (NMNs) with controlled size, morphology, composition or structure have becoming a major motive force behind the development of modern bioanalytical chemistry. In this chapter, a brief introduction is given to the history and progress of NMNs based bioanalysis. Particular attention is devoted to some representive works in the area of biosensing and biorecognition applications. The article is mainly categorized into absorbance-based assay, electrochemical detection and fluorescent analysis.