Abstract
Stereocontrolled synthesis of racemic and chiral novel beta-lactams using polyaromatic imines has been accomplished. Domestic and automated microwave-induced reactions have been investigated for the preparation of these types of beta-lactams. A preliminary mechanism of this reaction has been advanced. Formation of trans-beta-lactams has been explained through isomerization of the enolates formed during the reaction of acid chloride with imines in the presence of tertiary base. A donor-acceptor complex pathway has been believed to be involved in the formation of cis-beta-lactams. The effect of a peri hydrogen has been found to be significant in controlling the stereochemistry of the beta-lactams. Structure-activity relationship has identified beta-lactams with anticancer activity. The presence of an acetoxy group has proven very important for anticancer activity. The preparation and mechanism of action of several other new anticancer beta-lactams have also been explored.