Abstract
Protonated clusters of the type H+(CH3OH)n(CH3CN)m show a predominant sequence with the composition H+(CH3OH)n(CH3CN)2, where the solvent shells are completed by blocking groups on both ends [4]. Even though ionization involves large excess energies, the observed cluster distributions are sensitive to thermochemical differences as small as 1–3 kcal/mole. Nucleophilic substitution reactions have been observed following the ionization of p-difluorobenzene-methanol mixed clusters. The generation of p-fluoroanisole ion exhibits a strong dependence on the degree of solvation of the cluster. The results for different alcohols will be discussed.