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Single Nucleotide Polymorphism (SNP) Panels for Rapid Positional Cloning in Zebrafish
Book chapter   Peer reviewed

Single Nucleotide Polymorphism (SNP) Panels for Rapid Positional Cloning in Zebrafish

Matthew D. Clark, Victor Guryev, Ewart de Bruijn, Isaac J. Nijman, Masazumi Tada, Catherine Wilson, Panos Deloukas, John H. Postlethwait, Edwin Cuppen and Derek L. Stemple
Methods in Cell Biology, pp.221-235
Methods in Cell Biology, Elsevier
01/01/2011
PMID: 21924166

Abstract

Cell Biology Life Sciences & Biomedicine Science & Technology
Despite considerable genetic and genomic resources the positional cloning of forward mutations remains a slow and manually intensive task, typically using gel based genotyping and sequential rounds of mapping. We have used the latest genetic resources and genotyping technologies to develop two commercially available SNP panels of thousands of markers that can be used to speed up positional cloning.

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