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Recent synthetic methodologies for pyrazolo[1,5-a]pyrimidine
Review   Peer reviewed

Recent synthetic methodologies for pyrazolo[1,5-a]pyrimidine

Mohamed A. Salem, Mohamed H. Helal, Moustafa A. Gouda, Hala H. Abd EL-Gawad, Marwa A. M. Shehab and Abeer El-Khalafawy
Synthetic Communications, Vol.49(14), pp.1750-1776
18/07/2019
DOI: https://doi.org/10.1080/00397911.2019.1604967

Abstract

5-Aminopyrazole enaminonitriles pyrazolo[1,5-a]pyrimidines α,β-unsaturated ketones β-diketones β-ketoester
The development of new synthetic routes towards pyrazolo[1,5-a]pyrimidines for their biological and medicinal exploration is an attractive area for researchers. This review focuses on various synthetic routes developed in the last decade for the synthesis of differently substituted pyrazolo[1,5-a]pyrimidines by a broad range of organic reactions by means of 5-aminopyrazole as a precursor.

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