Abstract
We address a vehicle routing problem with time windows (VRPTW) that also contains vehicle with preventive maintenance constraints (VRPTW-PM) and propose a MIP mathematical formulation as well as a general variable neighborhood search metaheuristic (VNS) to solve with large instance the problematic situation. First we create a initial solution using Solomon heuristic then we minimize the number of used routes, and then the total travelled distance by all vehicles is minimized. Computational results show the efficiency of the proposed approach.