Abstract
Marine invertebrates are highly colonized by microorganisms up to 40˜50% of their cell mass. In many cases, the microbes are the real producer of the secondary metabolites. Marine fungi are a promising source of new pharmaceuticals, but there are very few reports about the chemistry of the marine fungi from the diverse Red Sea. In our search for bioactive compounds from marine microbes, we have investigated the marine-derived fungus
Penicillium
species. Bioassay-directed fractionation of the active fraction of the marine sponge-derived fungus,
Penicillium
species (SDA-27) resulted into the identification of several new bioactive compounds. The structures of the compounds were identified by extensive 1D and 2D NMR studies as well as high-resolution mass spectral determination. Different biological activities of the compounds will be presented.