Abstract
For the quantitative determination of ciprofloxacin (CPLX) in pharmaceutical formulation, a batch-type chemiluminescence (CL) method is described. In this study, it was observed that CPLX could enhance the CL emission of the Ru(phen)32+-Ce(IV) system and that this enhancement effect was dependent on the concentration of CPLX. Based on this, a CL system was established for the determination of CPLX. Under the optimum experimental conditions, the linear range and detection limit are 1.0 x 10-2-1.0 x 10-4 mol/L and 2.0 x 10-8 mol/L, respectively. The relative standard deviation (RSD) for 10 repeated measurements of 1.5 x 10' mol/L CPLX was 1.30%. The method was applied to the determination of CPLX in pharmaceutical formulations.