Abstract
Zinc is an important trace elements that necessary for activity of more than 300 enzymes including the enzymes of lipid metabolism, also it necessary for the activity of many receptors as peroxisome proliferator activated receptors (PPAR) which play an important role in lipid metabolism. This work was designed to study the effect of Zn deficiency on the gene expression of PPAR and its relation to lipolysis in the liver of chickens. 90 one-day-old male chicks were divided into three groups, control group, Zn deficient group and Zn supplemented group, at 21 day-old chickens were killed by cervical dislocation, liver samples were taken for investigation of PPAR (alpha, gamma and delta);Fatty acid translocase (FAT); fatty acid transport protein 1 (FATP1); beta-hydroxyacyl CoA dehydrogenase (HAD); long-chain acyl-CoA dehydrogenase (LCAD);" "hepatic triglyceride lipase (HTGL) and apolipoprotein B1 (ApoB1) genes expression, Zn concentration; hepatic triacylglycerols (IITAG); VLDL-TAG secretion, hepatic fatty acid beta-Oxidation and FFA content. The results indicate a significant decrease in the gene expression of all investigated"genes as well as hepatic Zn concentration, VLDL-TAG secretion and hepatic fatty acid beta-Oxidation in contrast a significant increase in HTAG and FFA in Zn deficient group. Zn supplementation accompanied with improve of all the result. It can be concluded that Zn is an important element for lipolysis in chicken liver and this mediated through it's effect on PPAR.