Formulation and antioxidant properties of curcumin gum Arabic nanoparticles for delivery to cancer cells

A. Hassani; S. A. Hussain; H. H. Enezei; S. Saeed; W. N. Ibrahim; M. S. Al-Qubaisi; H. Zentou; R. Rosli; A. A. Doolaanea

doi:10.1088/1757-899X/991/1/012101

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Formulation and antioxidant properties of curcumin gum Arabic nanoparticles for delivery to cancer cells

Conference proceeding

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Formulation and antioxidant properties of curcumin gum Arabic nanoparticles for delivery to cancer cells

A. Hassani, S. A. Hussain, H. H. Enezei, S. Saeed, W. N. Ibrahim, M. S. Al-Qubaisi, H. Zentou, R. Rosli and A. A. Doolaanea

5TH INTERNATIONAL CONFERENCE OF CHEMICAL ENGINEERING AND INDUSTRIAL BIOTECHNOLOGY (ICCEIB 2020), Vol.991(1), pp.012101/1-012101/5

IOP Conference Series-Materials Science and Engineering

01/12/2020

DOI: https://doi.org/10.1088/1757-899X/991/1/012101

Abstract

Biotechnology & Applied Microbiology

Energy & Fuels

Engineering

Engineering, Chemical

Engineering, Environmental

Food Science & Technology

Life Sciences & Biomedicine

Science & Technology

Technology

Curcumin nanoparticles (Cur/GANPs) were formulated based on gum arabic (GA) as a stabilizer coatings for nanoparticles through efficient synthesis approach. The current study investigated the antioxidant properties and antihypertensive activity of curcumin (Cur) using various established in vitro assays, such as 1,1-diphenyl-2-picrylhydrazyl (DPPH) as well as angiotensin converting enzyme (ACE) inhibitory activity. The in vitro cytotoxicity of Cur/GANPs against human liver cancer (HepG2), and colon cancer (HT29) was investigated. The exposure of human cancer cells to Cur/GANPs (1.56-100 g/ml) using MTT (3-(4,5-dimethylthiazol-2-yl) 2,5-diphenyl tetrazolium bromide) has revealed that the Cur/GANPs inhibited the growth of cell lines examined in a dose dependent manner. Hence, Cur/GANPs nanoparticles may have great potential to be applied for cancer treatment.

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Title: Formulation and antioxidant properties of curcumin gum Arabic nanoparticles for delivery to cancer cells
Creators - without role: A. Hassani - Universiti Putra Malaysia
S. A. Hussain - Universiti Putra Malaysia
H. H. Enezei - University of Anbar
S. Saeed - International Islamic University Malaysia
W. N. Ibrahim - Qatar University
M. S. Al-Qubaisi - Qatar University
H. Zentou - Universiti Putra Malaysia
R. Rosli - Universiti Putra Malaysia
A. A. Doolaanea - International Islamic University Malaysia
Contributors - without role: H D Setiabudi
SKA Mudalip
S Z Abidin
F N Chew
Publication Details: 5TH INTERNATIONAL CONFERENCE OF CHEMICAL ENGINEERING AND INDUSTRIAL BIOTECHNOLOGY (ICCEIB 2020), Vol.991(1), pp.012101/1-012101/5
Series: IOP Conference Series-Materials Science and Engineering
Publisher: Iop Publishing Ltd
Number of pages: 5
Grant note: P-RIGS18-026-0026; GP-IPS/2016/9505500 / Universiti Putra Malaysia International Islamic University Malaysia
Identifiers: 9941062508331
Academic Unit: King Abdullah University of Science & Technology
Language: English
Resource Type: Conference proceeding