Abstract
A miniaturized drug delivery system suitable for in vivo biomedical applications is presented. The system consists of an electrolytic pump driving a micro bellows membrane as an actuator for delivery through microneedles. A two-photon polymerization 3D printing technique was used to fabricate a reservoir equipped with microneedles. Analytical characterization of the flow rate through the microneedles showed an outgoing flow rate ranging from 63 mu L/min to 520 mu L/min for an applied pressure of 0.1 to 1 kPa. The assembled system with an overall size of 3.9 mm x 2.1 mm x 2 mm achieved delivery of 4 +/- 0.5 mu L within 12 seconds of actuation. A penetration test of the microneedle into a skin-like material confirms its potential for transdermal delivery.