Abstract
To determine the molecular changes that may be associated with defective embryogenesis in diabetic pregnancy, we have analyzed global differential gene expression using microarrays prepared from NIA 15K mouse cDNA library. Comparison of embryos of streptozotocin-induced severely-diabetic (SD) and non-diabetic (ND) mice revealed multiple dysregulation in transcriptional response under maternal diabetic milieu. Of the 15,012 genes surveyed, only 32 (0.21%) displayed a greater than two-fold under-expression, whilst 12 (0.08%) displayed a greater than two-fold over-expression. The identification of these genes will provide a foundation for understanding the molecular basis of diabetic embryopathy.