Abstract
In this paper, novel nano-yarn reinforced scaffolds were fabricated and further biomineralized by submerging in 10xsimulated body fluid (SBF). The compressive strength of P (LLA-CL)/ Silk fibroin (SF) nano-yarns reinforced scaffold was 1.72 +/- 0.50 MPa and its porosity is 82.8%. Fourier transform infrared spectrum (FTIR) and X-ray diffraction (XRD) data confirmed the mineral phase was made of hydroxyapatite (HA). MC3T3-E1 cell proliferation and differentiation on the scaffolds were evaluated. In vitro biological evaluation showed that HA coated scaffolds provided higher cell proliferation efficiency (t-test, p < 0.05) than uncoated scaffolds.