Abstract
Microbial natural products have historically played an important role in both antibacterial and antiparasitic drug discovery. However, with emerging drug resistance as a global threat to nearly all current antimicrobial treatments on the market, new discovery efforts are needed with increasing urgency. Mangrove endophytic fungi, known as a source of great biological and chemical diversity, were investigated in a large epigenetics based screening program. Cultured under control and epigenetically modified conditions, isolates were extracted and submitted for biological assay against the ESKAPE pathogens, the tropical disease causing parasite
Leishmania donovani
, and the meningoencephalitis causing amoeba
Naeglaria fowlerii
. The chemical investigation of one active organism identified in this way yielded a suite of new antimicrobial compounds. Herein, the structure elucidation and biological profiles of these new compounds will be discussed.