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Non-invasive dry mass determination and monitoring at the single cell level with digital holographic microscopy
Conference proceeding

Non-invasive dry mass determination and monitoring at the single cell level with digital holographic microscopy

Benjamin Rappaz, Elena Cano, Jonas Kuehn, Tristan Colomb, Christian Depeursinge, Pierre J. Magistretti and Pierre Marquet
BIOPHOTONICS: PHOTONIC SOLUTIONS FOR BETTER HEALTH CARE, Vol.6991(1), pp.699111-699114
Proceedings of SPIE
01/01/2008
DOI: https://doi.org/10.1117/12.781565

Abstract

Engineering Engineering, Biomedical Imaging Science & Photographic Technology Optics Physical Sciences Science & Technology Technology
Digital holography microscopy (DHM) is an optical microscopy technique which allows recording non-invasively the phase shift induced by living cells with nanometric sensitivity. Here, we exploit the phase signal as an indicator of dry mass (related to the protein concentration). This parameter allows monitoring the protein production rate and its evolution during the cell cycle.

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