Abstract
Various water soluble pharmaceutical compounds can be easily produced as fine particles using supercritical drying. As we show here, selective production of various polymorphs and pseudomorphs was demonstrated for amino acids - glycine and phen ylalanine - as model compounds. In addition, the particle morphology of protein particles - lysozyme - could also he controlled by appropriate selection of the process conditions. Finally, composite particles containing labile proteins and sugars or sugar and amino acid were produced In the first case, it was possible to stabilise the proteins - myoglobin and lysozyme - into a dry powder formulation containing sucrose or trehalose. In the second case, an amorphous or partially amorphous powder - sucrose and glycine - could be produced from two easily crystallisable compounds.