Abstract
With the quick developments of biomaterials and tissue engineering, functional electrospun nanofibers mimicing natural bone extracellular matrixc (ECM) have attracted a lot of attentions. In this paper, ten times simulated body fluid (10 x SBF) was employed to mineralize the electrospun P(LLA-CL)/Collagen composite nanofiberous scaffolds. Bone-like apatitic calcium phosphate was rapidly coated on the surface of the composite nanofiber within 2 similar to 6 h at room temperature. The structure and morphology of the coated nanofibers were characterized by Fourier transform infrared (FTIR) and scanning electron microscopy (SEM). X-ray diffraction (XRD) and Energy dispersive spectroscopy (EDS) were utilized to analyze the apatitic nature of the precipitates formed in 10 x SBF. The results showed that the coated composite nanofiberous scaffolds may have a great potential for bone tissue engineering.