Abstract
In recent years, Blockchain technology has been highly valued and disruptive. Several researches have presented a merge between blockchain and current application i.e. medical, supply chain, and e-commerce. Although Blockchain architecture does not have a standard yet, IBM, MS, AWS offer BaaS (Blockchain as a Service). In addition to the current public chains i.e. Ethereum,,NEO, and Cardeno; there are some differences between several public ledgers in terms of development and architecture. This paper introduces the main factors that affect integration of Artificial Intelligence with Blockchain. As well as, how it could be integrated for forecasting and automating; building self-regulated chain.