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1-Naphthol Synthesis through Base-Promoted SNAr Reactions of ortho-Haloacetophenones Followed by Lewis-Acid-Catalyzed Cyclization
Journal article   Peer reviewed

1-Naphthol Synthesis through Base-Promoted SNAr Reactions of ortho-Haloacetophenones Followed by Lewis-Acid-Catalyzed Cyclization

Xiaoqiang Yu, Peihong Zhu, Ming Bao, Yoshinori Yamamoto, Abdulrahman I. Almansour, Natarajan Arumugam and Raju Suresh Kumar
Asian journal of organic chemistry, Vol.5(5), pp.699-704
01/05/2016
DOI: https://doi.org/10.1002/ajoc.201600026

Abstract

Chemistry Chemistry, Organic Physical Sciences Science & Technology
An efficient method was developed for the synthesis of 1-naphthols through NaOtBu-promoted SNAr reaction of ortho-haloacetophenones followed by Lewis acid CuI-catalyzed intramolecular condensation and isomerization. 1-Naphthol derivatives were obtained in satisfactory yields from aryl bromide and aryl iodide substrates.

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