Abstract
The regiospecific synthesis of pyrazolines has been accomplished through the 1,3-dipolar cycloaddition of diazoalkanes. The reaction of 2-diazopropane 1 with monosubstituted alkenes 2 has been studied. It led to pyrazolines derivatives 3. In addition the reactivity of p-toluldiazomethane 4 towards alpha,beta-unsaturated enones 5 is reported, affording Delta(2)-pyrazolines. Products were screened for their antimycobacterial activity against Mycobacterium tuberculosis H37Rv strain.