Abstract
1,3,4-oxadiazole is an aromatic heterocycle with -N=C=O-linkage. 1,3,4-oxadiazole derivatives possess remarkable biological properties; antimicrobial anti-inflammatory, anti-cancer, antitubercular, antioxidant, antiviral, and anti-diabetic. This scaffold is present in many marketed drugs, such as Raltegravir, Tiodazosin, Nesapidil, and Zibotentan. 1,3,4-oxadiazole derivatives have displayed significant anti-cancer potential with a diverse mode of actions viz. growth factors, enzymes, kinases, etc. The present review gives an overview of the anti-cancer potential of 1,3,4-oxadiazoles derivatives in cancer drug discovery and development from the last ten years.