Abstract
The synthesis of novel bis(thiazoles) 20a-c and 23a-c is reported. Thus, reaction of 2-bromo-1( 5-methyl-1-phenyl-1H-pyrazol-4-yl) ethanone (6) with the corresponding thioamide derivatives 7a, b, in refluxing EtOH in the presence of triethylamine, afforded 4-pyrazolylthiazoles 8a, b in good yields. On the other hand, the novel bis(thiazoles) 20a-c and 23a-c were obtained from the reaction of 6 with the corresponding benzaldehyde thiosemicarbazones 19a-c, 22a-c in refluxing EtOH. Compounds 19a-c and 22a-c were obtained by condensation of the corresponding bis(aldehydes) 18a-c and 21a-c with thiosemicarbazide.