Abstract
The versatile synthons 2-ethoxy-3-(2-arylhydrazineylidene)chroman-4-ones were screened in vitro for anticancer activity against human colon, hepatocellular carcinoma, and Caucasian breast adenocarcinoma cell lines (HCT116, human hepatocellular carcinoma cell line 2 and MCF7) and for antimicrobial and antifungal activity against. The results show all tested compounds exhibit good to excellent anticancer efficacy against all the three tumor cell lines under study. One of them leads to perfect anticancer activity with a low selectivity index (SI) versus doxorubicin warrants further studies in both animals and humans; in addition, these compounds show good antimicrobial activity against most of the organisms under investigation.