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2,4-Diamino-6-(bis-2-chloroethyl)aminomethyl pteridine. A new potent anticancer drug
Journal article   Peer reviewed

2,4-Diamino-6-(bis-2-chloroethyl)aminomethyl pteridine. A new potent anticancer drug

M A Khaled, R D Morin, F Benington, J P Daugherty and Musad Abu Khaled
Cancer chemotherapy and pharmacology, Vol.13(2), pp.73-74
01/01/1984
DOI: https://doi.org/10.1007/BF00257116
PMID: 6547884

Abstract

Animals Antineoplastic Agents - therapeutic use Antineoplastic Agents - toxicity Female Leukemia L1210 - drug therapy Mice Mice, Inbred Strains Pteridines - therapeutic use Pteridines - toxicity
2,4-Diamino-6-(bis-2-chloroethyl)aminomethyl pteridine has been synthesized and found to be highly potent against L-1210 mouse leukemia lymphoblasts. A single dose of 5 mg/kg injected 24 h after the tumor inoculation increased the life-span of 50% of mice to more than 200%, while the other 50% of animals were cured.

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