Abstract
On the human genome, there are a lot of genes produced by duplication events. We determined human gene families by detecting duplicated genes among 35,005 genes in H-InvDB. We then detected chimpanzee, macaque, mouse and rat orthologs of the human gene members in each gene family. By analyzing these data, we estimated evolutionary conservation rates among gene families in mammalian and primate lineages. We obtained 26,715 human gene families in total. And 3,530 families contained more than one gene. The largest gene family was related to zinc finger and contained 606 genes. Out of the 606 genes, we found 555 genes (92%) had at least one ortholog. Categorizing all human genes into gene families and detecting the difference of the members among species could provide a new perspective on searching for candidate genes that account for human gene specificity.