Abstract
The interaction between 3-hydrazino-5,6-diphenyl-1,2,4-triazine (1) and chloroacetonitrile has produced 4-amino-7,8-diphenyl-1,2,4-triazino[4,3-b][1,2,4]triazine (2). The chemical reactivity of compound 2 was investigated by acylation, aroylation, thioacylation, and reaction with triphenylphosphine and diethyl hydrogen phosphite. Furthermore, compound 2 was reacted with cyanamide followed by ring closure reaction with malonic acid to produce the N-(1-(7,8-diphenyl-2H[1,2,4]triazino[4,3-b] [1,2,4]triazin-4-yl)-4,6-dioxo-1,4,5,6-tetrahydropyrimidin-2-yl)acetamide (11). The structures of new compounds were deduced from their elemental analysis and spectral measurements (Fourier-transform infrared, H-1 nuclear magnetic resonance [NMR], C-13 NMR, P-31 NMR, and mass spectra). Compounds 2-8 were screened for anti-mycobacterial activity and the compounds 5, 4, and 8 exhibited moderate activity while others poorly.
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