Abstract
We herein report the 5 alpha-reductase inhibitors, antiviral and anti-tumor activities of some synthesized heterocyclic cyanopyridone and cyanothiopyridone derivatives fused with steroidal structure. Initially the acute toxicity of the compounds was assayed via the determination of their LD50. All the compounds, except 3b, were interestingly less toxic than the reference drug (Prednisolone (R)). Seventeen heterocyclic derivatives containing a cyanopyridone or cyanothiopyridone rings fused to a steroidal moiety were synthesized and screened for their 5 alpha-reductase inhibitors, antiviral and anti-tumor activities comparable to that of Anastrozole, Bicalutamide, Efavirenz, Capravirine, Ribavirin, Oseltamivir and Amantadine as the reference drugs. Some of the compounds exhibited better 5 alpha-reductase inhibitors, antiviral and antitumor activities than the reference drugs. The detailed 5 alpha-reductase inhibitors, antiviral and anti-tumor activities of the synthesized compounds were reported. (C) 2011 Elsevier B.V. All rights reserved.