Abstract
In the title molecule {systematic name: N-[3-(diquino[3,2-b;2 ',3 '- e][1,4] thiazin-6-yl) propyl]-4-methylbenzenesulfonamide}, C28H24N4O2S2, the pentacyclic system is relatively planar [maximum deviation from the mean plane = 0.242 (1) angstrom]. The dihedral angle between two quinoline ring systems is 8.23 (2)degrees and that between the two halves of the 1,4-thiazine ring is 5.68 (3)degrees. The conformation adopted by the 3-(p-tolylsulfonylamino) propyl substituent allows for the formation of an intramolecular N-H center dot center dot center dot N hydrogen bond and places the benzene ring of this substituent above one of the quinoline fragments of the pentacyclic system. In the crystal, molecules are arranged via pi-pi stacking interactions into (011) layers [centroid-centroid distances = 3.981 (1)-4.320 (1) angstrom for the rings in the pentacyclic system and 3.645 (1) angstrom for the tolyl benzene rings]. In addition, molecules are involved in weak C-H center dot center dot center dot O, which connect the layers, and C-H center dot center dot center dot S hydrogen bonds. The title compound shows promising anticancer activity against renal cancer cell line UO-31.