Abstract
Starting from 7-hydroxy-4-methylcoumarin, some new coumarin derivatives were synthesized involving various reactions - condensation with aldehydes, alkylation, and reaction with hydrazine hydrate. The antibacterial properties of new coumarin derivatives were tested against gram positive and negative bacteria using the agar dilution procedure. The new coumarin derivatives were found effective against Salmonella typhimurium, Listeria monocytogenes, and Micrococcus luteus with moderate to high activity, and their minimum inhibitory concentrations ranging from 0.0024 to 1.25 mg/ml. Moreover, the antioxidant activity of these compounds were studied with the 1,1-diphenyl-2-picrylhydrazyl, and compared with (gallic acid "GA" and butylated hydroxytoluene). In addition, the new coumarin derivatives were screened for their antitumor activity. Compounds 2e and 2d exhibited the highest antitumor activity with IC50 values 6.85 mu g/mL against MCF-7 and 10.75 mu g/mL against MDA-MB-231, respectively.