Abstract
Neutron captures on
10B may be a neat way to provide some selectivity in a fast neutron beam: when the neutrons are thermalized in the tissue, they produce nuclear reaction with
10B nuclei, releasing energetic α particles and Li ions. Provided that a sufficient amount of
10B may be carried with a specific molecule
inside tumoral cells, a very efficient component of irradiation can be added.
Tumors like glioblastomas, soft tissues sarcomas or melanomas, which are highly radioresistant, may benefit of this potentiation to obtain better local control, while sparing more the normal tissues.
Results of tumor targeting with boronated compounds, of dosimetry and radiobiology in our fast neutron beam will be presented.