Abstract
Hemolytic disease of the fetus and newborn (HDN) is a condition in which the lifespan of an infant's red blood cells (RBCs) is shortened by the action of specific IgG antibody (ies) derived from the mother. These antibodies may be directed against Rhesus or other blood group antigens on fetal RBCs that are inherited from the father but are not expressed by the mother. The widespread use of Rh immune globulin has dramatically decreased occurrence of anti-D HDN among D-Negative pregnant women, but alloimmunization and importance of antigens other than D has increased. We report a case of HDN due to maternal Anti-E and anti-c in an O positive mother. The newborn received double phototherapy and exchange transfusion followed by a top up transfusion and was discharged with no further problems.