Abstract
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Irrespective of the presence of hyaluronic acid (Hyadent((R)), HyA), biphasic calcium phosphate (Maxresorb((R)), BCP) was capable of bone regeneration within the defects as early as four weeks with sustained bone remodeling even at 10 weeks. Further in vivo studies are required to evaluate whether the dose and molecular weight of HyA could potentially benefit osseous regeneration with bone graft materials.
Abstract The aim of this in vivo study was to evaluate the efficacy of biphasic calcium phosphate (Maxresorb((R)), BCP) used in combination with hyaluronic acid (Hyadent((R)), HyA) gel for regeneration of osseous defects in a rat model. Bilateral femoral condylar bone defects (3 mm diameter and 3 mm depth) were created in 40 male Wistar rats. The defects were grafted as group I (BCP only), group II (BCP + HyA), group III (HyA only), and group IV (empty control). At four weeks and 10 weeks, the bone specimens were evaluated using histological and histomorphometrical analyses to identify the newly formed bone area (NF-BA (%)), as well as the remaining BCP particles (R-BCP (%)). Light microscopic examination indicated the absence of an inflammatory reaction within the bone defects after four weeks or 10 weeks of implantation. Significant new bone regeneration was present in the bone defects grafted with BCP or BCP + HyA biomaterials, as early as four weeks, compared to control groups. The addition of HyA to BCP did not significantly improve bone regeneration at four weeks or 10 weeks. Nevertheless, its role in bone healing and regeneration warrants further investigation.