Abstract
In this study, a compact-cell sensor based on a plastic-membrane was introduced for the determination of ephedrine (EP) in pharmaceutical formulations. The sensing membrane of the sensor cell was made of either potassium tetrafluorophenyl borate (type-I) or N, N-bis-ethoxycarbony-1,4,7,10,13,16-hexaoxacyclooctadecane (type-II). The developed sensor exhibited typical Nernstian response (59.8 mV/decade) and high sensitivity (pM 6.2). The sensor was found to work in a pH range of 3.1-8.96 and showed good selectivity for EP relative to other organic and inorganic interferent. The sensor was applied effectively for the assessment of EP in different pharmaceutical formulations.