Abstract
3-Cyano-5-oxo-4(2-thienyl)-indeno[1,2-b]pyridin-2-[1H]thione
3
was prepared from indanone
1
with arylidene cyanoacetamide or from arylideneindanone
2
with cyanoacetamide. S-Alkylation of
3
with halogenated compounds afforded compounds
4a-h
. Compounds
4d-h
underwent ring closure with sodium ethoxide to produce indenothienopyridines
5
a-e
, respectively. Treatment of
3
using ethylchoroacetate or chloroacetone gave compounds
6
and
7
, respectively. Compounds
5a
and
5d
were reacted with carbon disulphide in pyridine to give compounds
8a
and
8b
. Most of the synthesized compounds were screened in vitro for their antimicrobial activities against four species of bacteria and six species of fungi using Chloramphenicol (5%) and Terbinafine (5%) as a standard.