Abstract
A total synthesis of riccardin C has been accomplished using a Corey–Seebach reaction to effect macrocyclisation. The versatility of the strategy has also been demonstrated with a mimetic synthesis of an unnatural bis(bibenzyl) analogue.
A total synthesis of riccardin C has been achieved using a Corey–Seebach reaction to effect macrocyclisation. By virtue of a common late‐stage intermediate, formal syntheses of cavicularin and asterelin A have also been realised. More importantly, the approach has been used mimetically to prepare a new unnatural macrocyclic bis(bibenzyl) core.