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A Facile Synthesis of Phenylacetic Acids via Willgerodt-Kindler Reaction Under PTC Condition
Journal article   Peer reviewed

A Facile Synthesis of Phenylacetic Acids via Willgerodt-Kindler Reaction Under PTC Condition

M. Mujahid Alam, Srinivas R. Adapa and mohammed alam
Synthetic communications, Vol.33(1), pp.59-63
01/03/2003
DOI: https://doi.org/10.1081/SCC-120015559

Abstract

Phenylacetic acids are efficiently synthesized from acetophenones via thiomorpholides under Phase Transfer Catalytic (PTC) condition. The reaction proceeds efficiently by using triethyl benzyl ammonium chloride (TEBA) as PTC and the reaction time decreased dramatically upto 1/5th (24-5) to afford pure products in good to excellent yield.

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