Abstract
The clinical management and decision-making process related to breast cancer are based on multiple histological indicators. This study aims to jointly predict the Ki-67 expression level, luminal A subtype and histological grade molecular biomarkers using a new deep multitask learning method with multiparametric magnetic resonance imaging. A multitask learning network structure was proposed by introducing a common-task layer and task-specific layers to learn the high-level features that are common to all tasks and related to a specific task, respectively. A network pretrained with knowledge from the ImageNet dataset was used and fine-tuned with MRI data. Information from multiparametric MR images was fused using the strategy at the feature and decision levels. The area under the receiver operating characteristic curve (AUC) was used to measure model performance. For single-task learning using a single image series, the deep learning model generated AUCs of 0.752, 0.722, and 0.596 for the Ki-67, luminal A and histological grade prediction tasks, respectively. The performance was improved by freezing the first 5 convolutional layers, using 20% shared layers and fusing multiparametric series at the feature level, which achieved AUCs of 0.819, 0.799 and 0.747 for Ki-67, luminal A and histological grade prediction tasks, respectively. Our study showed advantages in jointly predicting correlated clinical biomarkers using a deep multitask learning framework with an appropriate number of fine-tuned convolutional layers by taking full advantage of common and complementary imaging features. Multiparametric image series-based multitask learning could be a promising approach for the multiple clinical indicator-based management of breast cancer.