Abstract
Cancer is defined as an abnormal growth of human cells classified into benign and malignant. The site makes further classification of cancers of initiation and genomic underpinnings. Lung cancer displays extreme heterogeneity, making genomic classification vital for future targeted therapies. Especially considering lung cancers account for 1.76 million deaths worldwide annually. However, tumors do not always correlate to cancer as they can be benign, severely dysplastic (pre-cancerous), or malignant (cancerous). Lung cancer presents with ambiguous symptoms, thus is difficult to diagnose and is detected later compared to other cancers. Diagnosis relies heavily on radiology and invasive procedures. Different models developed employing Artificial Intelligence (AI), and Machine Learning (ML) have been used to classify various cancers. In this study, the authors propose a Genetic Folding Strategy (GFS) based model to predict lung cancer from a lung cancer dataset. We developed and implemented GF to improve Support Vector Machines (SVM) classification kernel functions and used it to classify lung cancer. We developed and implemented GF to improve SVM classification kernel functions and used it to classify lung cancer. Classification performance evaluations and comparisons between the authors' GFS model and three SVM kernels, linear, polynomial and radial basis function, were conducted thoroughly on real lung cancer datasets. While using GFS in classifying lung cancer, the authors obtained an accuracy of 96.2%. This is the highest current accuracy compared to other kernels.