A Genome-Wide Association Study of Type 2 Diabetes in Finns Detects Multiple Susceptibility Variants

Laura J. Scott; Karen L. Mohlke; Lori L. Bonnycastle; Cristen J. Willer; Yun Li; William L. Duren; Michael R. Erdos; Heather M. Stringham; Peter S. Chines; Anne U. Jackson; Ludmila Prokunina-Olsson; Chia-Jen Ding; Amy J. Swift; Narisu Narisu; Tianle Hu; Randall Pruim; Rui Xiao; Xiao-Yi Li; Karen N. Conneely; Nancy L. Riebow; Andrew G. Sprau; Maurine Tong; Peggy P. White; Kurt N. Hetrick; Michael W. Barnhart; Craig W. Bark; Janet L. Goldstein; Lee Watkins; Fang Xiang; Jouko Saramies; Thomas A. Buchanan; Richard M. Watanabe; Timo T. Valle; Leena Kinnunen; GoncÌ§alo R. Abecasis; Elizabeth W. Pugh; Kimberly F. Doheny; Richard N. Bergman; Jaakko Tuomilehto; Francis S. Collins; Michael Boehnke

doi:10.1126/science.1142382

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A Genome-Wide Association Study of Type 2 Diabetes in Finns Detects Multiple Susceptibility Variants

Journal article

Peer reviewed

A Genome-Wide Association Study of Type 2 Diabetes in Finns Detects Multiple Susceptibility Variants

Laura J. Scott, Karen L. Mohlke, Lori L. Bonnycastle, Cristen J. Willer, Yun Li, William L. Duren, Michael R. Erdos, Heather M. Stringham, Peter S. Chines, Anne U. Jackson, …

Science (American Association for the Advancement of Science), Vol.316(5829), pp.1341-1345

01/06/2007

DOI: https://doi.org/10.1126/science.1142382

PMCID: PMC3214617

PMID: 17463248

Abstract

Identifying the genetic variants that increase the risk of type 2 diabetes (T2D) in humans has been a formidable challenge. Adopting a genome-wide association strategy, we genotyped 1161 Finnish T2D cases and 1174 Finnish normal glucose-tolerant (NGT) controls with >315,000 single-nucleotide polymorphisms (SNPs) and imputed genotypes for an additional >2 million autosomal SNPs. We carried out association analysis with these SNPs to identify genetic variants that predispose to T2D, compared our T2D association results with the results of two similar studies, and genotyped 80 SNPs in an additional 1215 Finnish T2D cases and 1258 Finnish NGT controls. We identify T2D-associated variants in an intergenic region of chromosome 11p12, contribute to the identification of T2D-associated variants near the genes IGF2BP2 and CDKAL1 and the region of CDKN2A and CDKN2B , and confirm that variants near TCF7L2 , SLC30A8 , HHEX , FTO , PPARG , and KCNJ11 are associated with T2D risk. This brings the number of T2D loci now confidently identified to at least 10.

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Title: A Genome-Wide Association Study of Type 2 Diabetes in Finns Detects Multiple Susceptibility Variants
Creators - without role: Laura J. Scott - University of Michigan–Ann Arbor
Karen L. Mohlke - University of Michigan–Ann Arbor
Lori L. Bonnycastle - University of Michigan–Ann Arbor
Cristen J. Willer - University of Michigan–Ann Arbor
Yun Li - University of Michigan–Ann Arbor
William L. Duren - University of Michigan–Ann Arbor
Michael R. Erdos - University of Michigan–Ann Arbor
Heather M. Stringham - University of Michigan–Ann Arbor
Peter S. Chines - University of Michigan–Ann Arbor
Anne U. Jackson - University of Michigan–Ann Arbor
Ludmila Prokunina-Olsson - University of Michigan–Ann Arbor
Chia-Jen Ding - University of Michigan–Ann Arbor
Amy J. Swift - University of Michigan–Ann Arbor
Narisu Narisu - University of Michigan–Ann Arbor
Tianle Hu - University of Michigan–Ann Arbor
Randall Pruim - University of Michigan–Ann Arbor
Rui Xiao - University of Michigan–Ann Arbor
Xiao-Yi Li - University of Michigan–Ann Arbor
Karen N. Conneely - University of Michigan–Ann Arbor
Nancy L. Riebow - University of Michigan–Ann Arbor
Andrew G. Sprau - University of Michigan–Ann Arbor
Maurine Tong - University of Michigan–Ann Arbor
Peggy P. White - University of Michigan–Ann Arbor
Kurt N. Hetrick - University of Michigan–Ann Arbor
Michael W. Barnhart - University of Michigan–Ann Arbor
Craig W. Bark - University of Michigan–Ann Arbor
Janet L. Goldstein - University of Michigan–Ann Arbor
Lee Watkins - University of Michigan–Ann Arbor
Fang Xiang - University of Michigan–Ann Arbor
Jouko Saramies - University of Michigan–Ann Arbor
Thomas A. Buchanan - University of Michigan–Ann Arbor
Richard M. Watanabe - University of Michigan–Ann Arbor
Timo T. Valle - University of Michigan–Ann Arbor
Leena Kinnunen - University of Michigan–Ann Arbor
GoncÌ§alo R. Abecasis - University of Michigan–Ann Arbor
Elizabeth W. Pugh - University of Michigan–Ann Arbor
Kimberly F. Doheny - University of Michigan–Ann Arbor
Richard N. Bergman - University of Michigan–Ann Arbor
Jaakko Tuomilehto - University of Michigan–Ann Arbor
Francis S. Collins - University of Michigan–Ann Arbor
Michael Boehnke - University of Michigan–Ann Arbor
Publication Details: Science (American Association for the Advancement of Science), Vol.316(5829), pp.1341-1345
Identifiers: 9936322608331
Academic Unit: King Abdulaziz University
Language: English
Resource Type: Journal article