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A Human Pleiotropic Multiorgan Condition Caused by Deficient Wnt Secretion
Journal article   Peer reviewed

A Human Pleiotropic Multiorgan Condition Caused by Deficient Wnt Secretion

Guoliang Chai, Emmanuelle Szenker-Ravi, Changuk Chung, Zhen Li, Lu Wang, Muznah Khatoo, Trevor Marshall, Nan Jiang, Xiaoxu Yang, Jennifer McEvoy-Venneri, …
The New England journal of medicine, Vol.385(14), pp.1292-1301
30/09/2021
PMID: 34587386

Abstract

Birth Defects Genetics Genetics General Gynecology Obstetrics Pediatrics Pediatrics General
The Wnt proteins are soluble and secreted; they have fundamental roles in directing and maintaining cell behavior. This study implicates a gene critical to Wnt secretion in structural birth defects and provides proof of principle of pharmacologic amelioration in mouse models.

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