A Large Set of Finnish Affected Sibling Pair Families With Type 2 Diabetes Suggests Susceptibility Loci on Chromosomes 6, 11, and 14

Kaisa Silander; Laura J. Scott; Timo T. Valle; Karen L. Mohlke; Heather M. Stringham; Kerry R. Wiles; William L. Duren; Kimberly F. Doheny; Elizabeth W. Pugh; Peter Chines; Narisu Narisu; Peggy P. White; Tasha E. Fingerlin; Anne U. Jackson; Chun Li; Soumitra Ghosh; Victoria L. Magnuson; Kimberly Colby; Michael R. Erdos; Jason E. Hill; Pablo Hollstein; Kathleen M. Humphreys; Roshni A. Kasad; Jessica Lambert; Konstantinos N. Lazaridis; George Lin; Anabelle Morales-Mena; Kristin Patzkowski; Carrie Pfahl; Rachel Porter; David Rha; Leonid Segal; Yong D. Suh; Jason Tovar; Arun Unni; Christian Welch; Julie A. Douglas; Michael P. Epstein; Elizabeth R. Hauser; William Hagopian; Thomas A. Buchanan; Richard M. Watanabe; Richard N. Bergman; Jaakko Tuomilehto; Francis S. Collins; Michael Boehnke

doi:10.2337/diabetes.53.3.821

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A Large Set of Finnish Affected Sibling Pair Families With Type 2 Diabetes Suggests Susceptibility Loci on Chromosomes 6, 11, and 14

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A Large Set of Finnish Affected Sibling Pair Families With Type 2 Diabetes Suggests Susceptibility Loci on Chromosomes 6, 11, and 14

Kaisa Silander, Laura J. Scott, Timo T. Valle, Karen L. Mohlke, Heather M. Stringham, Kerry R. Wiles, William L. Duren, Kimberly F. Doheny, Elizabeth W. Pugh, Peter Chines, …

Diabetes (New York, N.Y.), Vol.53(3), pp.821-829

01/03/2004

DOI: https://doi.org/10.2337/diabetes.53.3.821

PMID: 14988269

Abstract

The aim of the Finland-United States Investigation of NIDDM Genetics (FUSION) study is to identify genes that predispose to type 2 diabetes or are responsible for variability in diabetes-related traits via a positional cloning and positional candidate gene approach. In a previously published genome-wide scan of 478 Finnish affected sibling pair (ASP) families (FUSION 1), the strongest linkage results were on chromosomes 20 and 11. We now report a second genome-wide scan using an independent set of 242 Finnish ASP families (FUSION 2), a detailed analysis of the combined set of 737 FUSION 1 + 2 families (495 updated FUSION 1 families), and fine mapping of the regions of chromosomes 11 and 20. The strongest FUSION 2 linkage results were on chromosomes 6 (maximum logarithm of odds score [MLS] = 2.30 at 95 cM) and 14 (MLS = 1.80 at 57 cM). For the combined FUSION 1 + 2 families, three results were particularly notable: chromosome 11 (MLS = 2.98 at 82 cM), chromosome 14 (MLS = 2.74 at 58 cM), and chromosome 6 (MLS = 2.66 at 96 cM). We obtained smaller FUSION 1 + 2 MLSs on chromosomes X (MLS = 1.27 at 152 cM) and 20p (MLS = 1.21 at 20 cM). Among the 10 regions that showed nominally significant evidence for linkage in FUSION 1, four (on chromosomes 6, 11, 14, and X) also showed evidence for linkage in FUSION 2 and stronger evidence for linkage in the combined FUSION 1 + 2 sample.

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Title: A Large Set of Finnish Affected Sibling Pair Families With Type 2 Diabetes Suggests Susceptibility Loci on Chromosomes 6, 11, and 14
Creators - without role: Kaisa Silander - National Human Genome Research Institute
Laura J. Scott - University of Michigan–Ann Arbor
Timo T. Valle - Diabetes and Genetic Epidemiology Unit, Department of Epidemiology and Health Promotion, and Department of Biochemistry, National Public Health Institute, Helsinki, Finland
Karen L. Mohlke - National Human Genome Research Institute
Heather M. Stringham - University of Michigan–Ann Arbor
Kerry R. Wiles - National Human Genome Research Institute
William L. Duren - University of Michigan–Ann Arbor
Kimberly F. Doheny - Center for Inherited Disease Research, Institute of Genetic Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland
Elizabeth W. Pugh - Center for Inherited Disease Research, Institute of Genetic Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland
Peter Chines - National Human Genome Research Institute
Narisu Narisu - National Human Genome Research Institute
Peggy P. White - University of Michigan–Ann Arbor
Tasha E. Fingerlin - University of Michigan–Ann Arbor
Anne U. Jackson - University of Michigan–Ann Arbor
Chun Li - University of Michigan–Ann Arbor
Soumitra Ghosh - National Human Genome Research Institute
Victoria L. Magnuson - National Human Genome Research Institute
Kimberly Colby - National Human Genome Research Institute
Michael R. Erdos - National Human Genome Research Institute
Jason E. Hill - National Human Genome Research Institute
Pablo Hollstein - National Human Genome Research Institute
Kathleen M. Humphreys - National Human Genome Research Institute
Roshni A. Kasad - National Human Genome Research Institute
Jessica Lambert - National Human Genome Research Institute
Konstantinos N. Lazaridis - National Human Genome Research Institute
George Lin - National Human Genome Research Institute
Anabelle Morales-Mena - National Human Genome Research Institute
Kristin Patzkowski - National Human Genome Research Institute
Carrie Pfahl - National Human Genome Research Institute
Rachel Porter - National Human Genome Research Institute
David Rha - National Human Genome Research Institute
Leonid Segal - National Human Genome Research Institute
Yong D. Suh - National Human Genome Research Institute
Jason Tovar - National Human Genome Research Institute
Arun Unni - National Human Genome Research Institute
Christian Welch - National Human Genome Research Institute
Julie A. Douglas - University of Michigan–Ann Arbor
Michael P. Epstein - University of Michigan–Ann Arbor
Elizabeth R. Hauser - University of Michigan–Ann Arbor
William Hagopian - Pacific Northwest Diabetes Research Institute
Thomas A. Buchanan - University of Southern California
Richard M. Watanabe - University of Southern California
Richard N. Bergman - University of Southern California
Jaakko Tuomilehto - University of Helsinki
Francis S. Collins - National Human Genome Research Institute
Michael Boehnke - University of Michigan–Ann Arbor
Publication Details: Diabetes (New York, N.Y.), Vol.53(3), pp.821-829
Identifiers: 9936177308331
Academic Unit: King Abdulaziz University
Language: English
Resource Type: Journal article