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A Mild Approach for the Synthesis of Indoles from N-(2-Iodo-aryl) formamides and Phenylacetylene by a Copper(I)- and Palladium-Catalyzed Cascade Process
Journal article   Peer reviewed

A Mild Approach for the Synthesis of Indoles from N-(2-Iodo-aryl) formamides and Phenylacetylene by a Copper(I)- and Palladium-Catalyzed Cascade Process

Atiur Ahmed, Munmun Ghosh, Shubhendu Dhara and Jayanta K. Ray
Synlett, Vol.25(17), pp.2455-2458
01/10/2014
DOI: https://doi.org/10.1055/s-0034-1378899

Abstract

Chemistry Chemistry, Organic Physical Sciences Science & Technology
An efficient one-pot copper(I)- and palladium-catalyzed synthesis of indoles from N-(2-iodo-aryl) formamides and phenylacetylene is described. The cascade reaction comprises a Sonogashira cross-coupling, an intramolecular C-N bond formation, and hydrolysis of the intermediate indole-1-carbaldehyde promoted by the same catalyst and base systems.

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