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A New Simplified Protocol for Copper(I) Alkyne-Azide Cycloaddition Reactions Using Low Substoichiometric Amounts of Copper(II) Precatalysts in Methanol
Journal article   Peer reviewed

A New Simplified Protocol for Copper(I) Alkyne-Azide Cycloaddition Reactions Using Low Substoichiometric Amounts of Copper(II) Precatalysts in Methanol

Benjamin R. Buckley, Maria M. P. Figueres, Amna N. Khan and Harry Heaney
Synlett, Vol.27(1), pp.51-56
04/01/2016
DOI: https://doi.org/10.1055/s-0035-1560526

Abstract

Chemistry Chemistry, Organic Physical Sciences Science & Technology
Copper(II) carboxylates are reduced efficiently by methanol in the presence of alkynes and form yellow alkynylcopper(I) polymeric precatalysts that are involved with azides, in the absence of added ligands, in the catalytic cycles that result in the formation of 1,4-disubstituted 1,2,3-triazoles.

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