Abstract
Abstract
AlCl
3
-mediated intramolecular cyclization of N,N-bis(1H-1,2,3-benzotriazol-1-ylmethyl)-3-phenyl-1-propanamine (5) gave 2-benzotriazolylmethyl-2,3,4,5-tetrahydro-1H-2-benzazepine (6). Subsequent nucleophilic substitution of the benzotriazolyl group in 6 with Grignard reagents, triethyl phosphite and sodium borohydride afforded 2,3,4,5-tetrahydro-1H-2-benzazepines 1A-E, 2 and 3. Similarly, TiCl
4
-mediated cyclization of 8 and 10 gave 5,6,7,13b-tetrahydro-9H-isoindolo[1,2-A][2]benzazepin-9-one (9) and 1,2,5,6,7,11b-hexahydro-3H-pyrrolo[2,1-A][2]benzazepin-3-one (11), respectively.