Abstract
One novel dimeric naphthoquinone, 1′,4′-dihydroxy-5,8-dimethoxy-11,11′-dimethyl-[7,3′-binaphthalene]-1,4,5′,8′-tetraone, was isolated from the chloroform-soluble fraction of Diospyros lotus bark. The chemical structure of compound
1
was elucidated by advanced spectroscopy techniques, such as
1
H,
13
C NMR, HMBC, HSQC, COSY, and NOSEY. The chloroform extract and compound
1
were evaluated for their urease inhibitory activity, which showed excellent results with IC
50
value of 421.21 and 68.42 μM, respectively, against thiourea (IC
50
= 21.24 μM).