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A Novel Peptide Hydrogel for an Antimicrobial Bandage Contact Lens
Journal article   Open access  Peer reviewed

A Novel Peptide Hydrogel for an Antimicrobial Bandage Contact Lens

Andrew G Gallagher, Jamal A Alorabi, Donald A Wellings, Rebecca Lace, Mal J Horsburgh and Rachel L Williams
Advanced healthcare materials, Vol.5(16), pp.2013-2018
08/2016
PMID: 27276231

Abstract

Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Contact Lenses Cornea - microbiology Epithelial Cells - microbiology Escherichia coli - growth & development Humans Hydrogels - chemistry Hydrogels - pharmacology Penicillin G - chemistry Penicillin G - pharmacology Polylysine - chemistry Polylysine - pharmacology Staphylococcus aureus - growth & development
A peptide hydrogel with an antimicrobial activity is developed as a bandage contact lens. The antimicrobial activity is enhanced with the addition of the biomolecules penicillin G or poly-ε-lysine and is positive against Staphylococcus aureus and Escherichia coli. The lens is also noncytotoxic toward a human corneal epithelial cell line and as a consequence is of great potential as a drug-eluting bandage lens replacing conventional corneal ulcer treatment.
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https://doi.org/10.1002/adhm.201600258View
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