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A Novel Synthetic Route to Dihydro- and α-Hydroxytetrahydro-furan Derivatives
Journal article   Peer reviewed

A Novel Synthetic Route to Dihydro- and α-Hydroxytetrahydro-furan Derivatives

Alan R. Katritzky and Irina V. Shcherbakova
Synthetic communications, Vol.26(7), pp.1385-1399
01/04/1996

Abstract

1-(3-Morpholinoprop-2-enyl)benzotriazole (1) provides a three carbon unit for the construction of dihydro- and tetrahydro-furan rings by one pot procedures. Lithiation of 1 followed by reaction with diaryl ketones gave 2,5-dihydro- and/or α-hydroxytetrahydro-furans, whereas successive reactions with iodoalkanes and diaryl ketones yielded 2,3-dihydrofurans.

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